The final time these two sides met was back in February and the Saints have been on the receiving finish of a 9-0 thrashing at Old Trafford.
Southampton suffered a 3-1 defeat towards Everton on the opening day, regardless of taking the lead by way of Adam Armstrong, who scored on his Saints debut. In the meantime United thrashed Leeds 5-1 at Outdated Trafford, with Bruno Fernandes bagging a hat-trick, to ship them prime of the desk on the opening day.
Manchester United have made two adjustments, with Martial and Matic coming into the workforce, with James and McTominay lacking out. Varane might make his United debut from the bench.
Ralph Hasenhuttl names the identical workforce that have been crushed by Everton final weekend, with Adams and Armstrong main the assault for the hosts.
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